SCHEMBL758610

SCHEMBL758610

Oc1cc(F)c(Cl)c(F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.50
HPGD P15428 4/20 0.50
CYP3A4 P08684 3/20 0.50
CRHBP P24387 1/20 0.50
CRHR2 Q13324 1/20 0.50
CHRM1 P11229 1/20 0.46
ALOX15 P16050 1/20 0.46
MAOA P21397 1/20 0.46
TBXA2R P21731 1/20 0.46
ADRA1A P35348 1/20 0.46
HTR2B P41595 1/20 0.46
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA9 Q16790 1/20 0.45
TAAR1 Q96RJ0 1/20 0.44
ESR1 P03372 9/20 0.41
ESR2 Q92731 8/20 0.41
BACE1 P56817 1/20 0.41
TSHR P16473 3/20 0.36
CASP1 P29466 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11714372 0.86 HSD17B10 (0.65) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL29745613 0.86 HSD17B10 (0.65) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL30701985 0.82 CYP3A4 (0.40) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL20045407 0.82 CYP3A4 (0.68) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL22112026 0.82 CYP3A4 (0.40) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL3155200 0.77 CYP3A4 (0.50) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL20132899 0.77 ALOX15 (0.42) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL1156272 0.75 HSD17B10 (0.50) HSD17B10HPGDCYP3A4CRHBPCRHR2
SCHEMBL12917725 0.75 ESR1 (0.56) CYP3A4ESR1ESR2
SCHEMBL30225848 0.75 HSD17B10 (0.50) HSD17B10HPGDCYP3A4CRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026102212-A1 MACROCYCLIC MCL-1 INHIBITORS VANDERBILT UNIVERSITY (US) 2026-05-15 WO disclosed
US-12421193-B2 GPR52 modulators and methods of use NEUROCRINE BIOSCIENCES, INC. (US) 2025-09-23 US disclosed
US-20250188071-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2025-06-12 US disclosed
US-12258338-B2 Modulators of the integrated stress response pathway EVOTEC INTERNATIONAL GMBH (DE) 2025-03-25 US disclosed
US-20230234925-A1 GPR52 MODULATORS AND METHODS OF USE NEUROCRINE BIOSCIENCES, INC. 2023-07-27 US disclosed
US-20230234925-A1 GPR52 MODULATORS AND METHODS OF USE NEUROCRINE BIOSCIENCES, INC. 2023-07-27 US disclosed
EP-4139284-A1 GPR52 MODULATORS AND METHODS OF USE Neurocrine Biosciences, Inc. (US) 2023-03-01 EP disclosed
US-20220227747-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC (UK) LIMITED (GB) 2022-07-21 US disclosed
WO-2021216705-A1 GPR52 MODULATORS AND METHODS OF USE NEUROCRINE BIOSCIENCES, INC. (US) 2021-10-28 WO disclosed
WO-2021216705-A1 GPR52 MODULATORS AND METHODS OF USE NEUROCRINE BIOSCIENCES, INC. (US) 2021-10-28 WO disclosed
EP-2098583-A2 Optically isotropic liquid crystal medium and optical device Chisso Corporation (JP) 2009-09-09 EP disclosed
US-20090135368-A1 OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE CHISSO CORPORATION (JP) 2009-05-28 US disclosed
US-20090135368-A1 OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE CHISSO CORPORATION (JP) 2009-05-28 US disclosed
US-20090135368-A1 OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE CHISSO CORPORATION (JP) 2009-05-28 US disclosed
EP-1650285-B1 Liquid crystal composition containing an optically active compound and liquid crystal electro-optical element SEIMI CHEM KK (JP) 2008-04-30 EP disclosed
EP-0637623-B1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK & CHEMICALS (JP) 2001-10-04 EP disclosed
US-5536443-A DUTERIUM CONTAINING COMPOUNDS FOOR ELECTROOPTICAL APPARATUS DAINIPPON INK & CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5474707-A Electrooptic display DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-12-12 US disclosed
EP-0637623-A1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-02-08 EP disclosed
US-4060562-A SULFUR CONTAINING CATALYST BAYER AKTIENGESELLSCHAFT (DT) 1977-11-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12258338-B2 Modulators of the integrated stress response pathway CRHR2, CRHR1, CRH HSD17B10 1698/4885HPGD 2475/4885CYP3A4 239/4885
US-20250188071-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY CRHR2, CRHR1, CRH HSD17B10 1698/4885HPGD 2475/4885CYP3A4 239/4885
US-20220227747-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY CRHR2, CRHR1, CRH HSD17B10 1698/4885HPGD 2475/4885CYP3A4 239/4885
US-20230234925-A1 GPR52 MODULATORS AND METHODS OF USE GPR52, GPR68, GPR35 HSD17B10 1107/4885HPGD 979/4885CYP3A4 2659/4885
US-12421193-B2 GPR52 modulators and methods of use GPR52, GPR68, GPR35 HSD17B10 1107/4885HPGD 979/4885CYP3A4 2659/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.