Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | ACLY | P53396 | 3/20 | 0.55 |
| ▸ | UQCRB | P14927 | 3/20 | 0.53 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594976 | 0.86 | UQCRB (0.51) | MEN1KMT2AMAPK1GAAMAPT | |
| SCHEMBL7589388 | 0.82 | CCR2 (0.54) | MEN1KMT2AGAAHSD17B2CA12 | |
| SCHEMBL7595505 | 0.79 | KEAP1 (0.59) | MEN1KMT2ACA2TSHR | |
| SCHEMBL5956125 | 0.79 | ALDH1A1 (0.59) | GAAMAPTHTTCA12CA2 | |
| SCHEMBL7587644 | 0.79 | CES1 (0.58) | — | |
| SCHEMBL7594857 | 0.78 | CA1 (0.54) | MEN1KMT2AGAAHTTCA12 | |
| SCHEMBL31681420 | 0.76 | ALDH1A1 (0.71) | MEN1KMT2AMAPK1GAAMAPT | |
| SCHEMBL3259826 | 0.76 | GAA (1.00) | MEN1KMT2AMAPK1GAAMAPT | |
| SCHEMBL812677 | 0.76 | KMT2A (0.77) | MEN1KMT2AMAPK1GAAMAPT | |
| SCHEMBL7594450 | 0.75 | CA2 (0.58) | CA12CA2LMNACA9EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |