SCHEMBL7588694

SCHEMBL7588694

COc1cccc(CCNC(=O)N(S)c2cc[c]cc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.51
MTNR1A P48039 2/20 0.50
MTNR1B P49286 2/20 0.50
CNR1 P21554 1/20 0.49
ALDH1A1 P00352 2/20 0.48
POLB P06746 1/20 0.48
CHRM2 P08172 1/20 0.48
CHRM1 P11229 1/20 0.48
CHRM3 P20309 1/20 0.48
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47
CA14 Q9ULX7 1/20 0.47
HDAC1 Q13547 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
OPRM1 P35372 1/20 0.45
OPRD1 P41143 1/20 0.45
OPRK1 P41145 1/20 0.45
HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7588977 0.86 SMN1; SMN2 (0.55) RAB9ACNR1ALDH1A1SMN1; SMN2
SCHEMBL6819677 0.84 CA1 (0.53) RAB9AMTNR1AMTNR1BCNR1ALDH1A1
SCHEMBL7783082 0.83 CA12 (0.55) ALDH1A1CA1CA2CA9HTT
SCHEMBL7589548 0.82 HDAC3 (0.36) MTNR1AMTNR1BCNR1ALDH1A1HDAC1
SCHEMBL7872178 0.82 CNR1 (0.46) RAB9ACNR1CA1CA2HDAC1
SCHEMBL7673079 0.82 ALDH1A1 (0.51) RAB9ACNR1ALDH1A1POLBHTT
SCHEMBL7585551 0.82 CNR1 (0.46) CNR1ALDH1A1POLBOPRM1OPRD1
SCHEMBL7598148 0.77 RAB9A (0.55) RAB9ACNR1ALDH1A1POLBSMN1; SMN2
SCHEMBL7860613 0.77 MTNR1A (0.56) RAB9AMTNR1AMTNR1BCNR1ALDH1A1
SCHEMBL17143946 0.76 ALDH1A1 (0.74) RAB9AMTNR1AMTNR1BCNR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144399-A3 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP Wyeth (US) 2002-09-11 EP disclosed
EP-1144399-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-17 EP disclosed
WO-2000034261-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed