Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 2/20 | 0.47 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588694 | 0.86 | RAB9A (0.51) | SMN1; SMN2ALDH1A1RAB9ACNR1 | |
| SCHEMBL7783082 | 0.84 | CA12 (0.55) | SMN1; SMN2KMT2AALDH1A1GAA | |
| SCHEMBL7599731 | 0.83 | CNR1 (0.42) | SMN1; SMN2KMT2ATAAR1ALDH1A1FPR2 | |
| SCHEMBL7594776 | 0.83 | HPGD (0.46) | SMN1; SMN2KMT2ATAAR1ALDH1A1PLAAT3 | |
| SCHEMBL7645916 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL7866856 | 0.80 | PLAAT3 (0.46) | KMT2APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL7585619 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2ATAAR1ALDH1A1NPC1 | |
| SCHEMBL7860613 | 0.78 | MTNR1A (0.56) | SMN1; SMN2KMT2ATAAR1ALDH1A1NPC1 | |
| SCHEMBL7598233 | 0.76 | FPR2 (0.61) | SMN1; SMN2KMT2AALDH1A1FPR2NPC1 | |
| SCHEMBL5186182 | 0.75 | RAB9A (0.64) | SMN1; SMN2KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144399-A3 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | Wyeth (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1144399-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034261-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |