Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591663 | 0.94 | CHRNB2 (0.42) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| SCHEMBL7582197 | 0.93 | CHRNB2 (0.41) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| SCHEMBL7590631 | 0.90 | ADRB1 (0.46) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| SCHEMBL7587237 | 0.83 | CHRNB2 (0.48) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| SCHEMBL7584867 | 0.80 | CHRNB2 (0.45) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| SCHEMBL7590671 | 0.80 | CHRNB2 (0.45) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| SCHEMBL7587341 | 0.76 | ADRB1 (0.62) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| SCHEMBL7591694 | 0.72 | DRD2 (0.39) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL7585657 | 0.69 | CHRM2 (0.43) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL7584881 | 0.68 | ALDH1A1 (0.42) | CHRNB2CHRNA4ADRB1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |