Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.32 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8781677 | 0.84 | ALDH1A1 (0.36) | DRD2ALDH1A1TRPV6TRPV5MAPT | |
| SCHEMBL8781567 | 0.81 | ALDH1A1 (0.34) | DRD2ALDH1A1OPRM1VNN1TRPV6 | |
| SCHEMBL25433642 | 0.80 | SLC6A2 (0.33) | DRD2SIGMAR1ALDH1A1VNN1MAPT | |
| SCHEMBL20751420 | 0.76 | PRKAB2 (0.39) | ALDH1A1IDH1KMT2A | |
| SCHEMBL6041455 | 0.76 | KMT2A (0.38) | DRD2ALDH1A1OPRM1KMT2A | |
| SCHEMBL6955508 | 0.72 | DRD2 (0.34) | DRD2ALDH1A1OPRM1TRPV6TRPV5 | |
| SCHEMBL652586 | 0.71 | DRD2 (0.68) | DRD2SIGMAR1ALDH1A1OPRM1MAPKAPK2 | |
| SCHEMBL187716 | 0.69 | DRD2 (1.00) | DRD2OPRM1MAPKAPK2KMT2A | |
| SCHEMBL615480 | 0.69 | DRD2 (0.66) | DRD2SIGMAR1OPRM1 | |
| SCHEMBL613058 | 0.69 | DRD2 (0.66) | DRD2SIGMAR1OPRM1MAPKAPK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076440-A2 | METHODS OF TREATING ALZHEIMER'S DISEASE WITH PIPERIDIN DERIVATES | ELAN PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |