Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.34 |
| ▸ | DRD3 | P35462 | 7/20 | 0.34 |
| ▸ | DRD4 | P21917 | 6/20 | 0.34 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.34 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6041455 | 0.81 | KMT2A (0.38) | DRD2DRD3DRD4KMT2AMEN1 | |
| SCHEMBL8781677 | 0.74 | ALDH1A1 (0.36) | DRD2TRPV6TRPV5KMT2AHRH3 | |
| SCHEMBL7589972 | 0.72 | DRD2 (0.53) | DRD2TRPV6TRPV5KMT2AOPRM1 | |
| SCHEMBL8781567 | 0.71 | ALDH1A1 (0.34) | DRD2TRPV6TRPV5OPRM1OPRK1 | |
| SCHEMBL20751420 | 0.67 | PRKAB2 (0.39) | KMT2AGRIN2BALDH1A1 | |
| SCHEMBL6956779 | 0.65 | CHRNB2 (0.43) | KMT2AMEN1OPRL1GRIN2BALDH1A1 | |
| SCHEMBL25433642 | 0.65 | SLC6A2 (0.33) | DRD2ALDH1A1 | |
| SCHEMBL29111308 | 0.63 | DRD2 (0.56) | DRD2KMT2AMEN1OPRM1OPRK1 | |
| SCHEMBL4069282 | 0.62 | CYP3A4 (0.32) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL4072998 | 0.61 | OTUD7B (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |