Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844764 | 0.81 | AKR1B1 (0.50) | PARP1AKR1B1 | |
| SCHEMBL31478167 | 0.76 | AKR1B1 (0.58) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL31478141 | 0.75 | LMNA (0.46) | ALDH1A1LMNAHPGDCYP1A2CYP2C19 | |
| SCHEMBL9313893 | 0.73 | KDM4E (0.60) | ALDH1A1LMNAPARP1MEN1KMT2A | |
| SCHEMBL7650955 | 0.73 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| Ammonia Solution, Strong SCHEMBL7590346 | 0.72 | MTNR1A (0.44) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL10616782 | 0.71 | SIGMAR1 (0.52) | ALDH1A1MEN1KMT2ACYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL28989826 | 0.71 | KDM4E (0.58) | ALDH1A1LMNAPARP1MEN1KMT2A | |
| SCHEMBL12608352 | 0.71 | ALDH1A1 (0.54) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL10665217 | 0.71 | PARP1 (0.46) | ALDH1A1PARP1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368573-B1 | MEASURING MYOCARDIAL FUNCTION IN MAMMAL | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2002-04-09 | — | — | US | disclosed |
| US-5063233-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-11-05 | — | — | US | disclosed |
| US-5034381-A | Antagonist | CIBA-GEIGY CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
| US-4968697-A | ADENOSINE-2 RECEPTOR AGONISTS | CIBA-GEIGY CORPORATION (US) | 1990-11-06 | — | — | US | disclosed |
| US-4954504-A | Hypotensive agents, psychotic disorders | CIBA-GEIGY CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0323807-A2 | Certain 2-substituted adenosine derivatives | CIBA-GEIGY AG (CH) | 1989-07-12 | — | — | EP | disclosed |
| EP-0277917-A2 | Certain adenosine 5'-carboxamide derivatives | CIBA-GEIGY AG (CH) | 1988-08-10 | — | — | EP | disclosed |
| EP-0267878-A1 | N9-cyclopentyl-substituted adenine derivatives | CIBA-GEIGY AG (CH) | 1988-05-18 | — | — | EP | disclosed |