Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 8/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 6/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.44 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.44 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9158591 | 0.97 | ITGB3 (0.48) | PRSS1PRSS2PRSS3TPSAB1CTSL | |
| SCHEMBL11066257 | 0.86 | CTSL (0.55) | CTSLCTSBCTSS | |
| SCHEMBL11546767 | 0.84 | L3MBTL1 (0.41) | SIRT2SIRT1SIRT3DPP4 | |
| SCHEMBL29087638 | 0.83 | PRSS1 (0.54) | PRSS1PRSS2PRSS3TPSAB1CTSL | |
| SCHEMBL9752532 | 0.82 | CTSL (0.52) | CTSLCTSBCTSS | |
| SCHEMBL1841203 | 0.81 | PRSS1 (0.61) | PRSS1PRSS2PRSS3TPSAB1CTSL | |
| SCHEMBL10723335 | 0.81 | PRSS1 (0.61) | PRSS1PRSS2PRSS3TPSAB1CTSL | |
| SCHEMBL1841202 | 0.81 | PRSS1 (0.61) | PRSS1PRSS2PRSS3TPSAB1CTSL | |
| SCHEMBL16494584 | 0.81 | HDAC1 (0.55) | PRSS1PRSS2PRSS3TPSAB1CTSL | |
| SCHEMBL648254 | 0.81 | HDAC1 (0.55) | PRSS1PRSS2PRSS3TPSAB1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | disclosed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | disclosed |