SCHEMBL7594470

SCHEMBL7594470

O=C(Nc1c(I)c(CO)c(I)c(NC(=O)C(O)C(O)CO)c1I)C(O)C(O)CO

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7589285 0.83 LMNA (0.41) LMNASMN1; SMN2
SCHEMBL7593885 0.82 LMNA (0.44) LMNASMN1; SMN2
SCHEMBL11217136 0.76 SMN1; SMN2 (0.45) LMNASMN1; SMN2
SCHEMBL7590127 0.71 LMNA (0.47) LMNASMN1; SMN2
SCHEMBL3919922 0.71 LMNA (0.50) LMNASMN1; SMN2
SCHEMBL13220206 0.71 LMNA (0.50) LMNASMN1; SMN2
SCHEMBL7591801 0.70 LMNA (0.62) LMNASMN1; SMN2
SCHEMBL6265502 0.70 LMNA (0.33) LMNASMN1; SMN2
SCHEMBL7590516 0.70 LMNA (0.39) LMNASMN1; SMN2
Ioglucomide SCHEMBL668426 0.69 SMN1; SMN2 (0.52) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6448442-B1 X-RAY CONTRAST AGENTS; LOW VISCOSITY IODINATED ARYL COMPOUNDS AMERSHAM HEALTH AS (NO) 2002-09-10 US disclosed
US-6310243-B1 BENZENE COMPOUNDS IN WHICH 3 NON-ADJACENT RING ATOMS ARE SUBSTITUTED WITH IODINE, 2 OF THE REMAINING RING ATOMS ARE AMIDE SUBSTITUTED WITH HYDROXY AND THE OTHER REMAINING RING ATOM IS A NON-AMIDE, HYDROXY-SUBSTITUTED NONIONIC MOIETY NYCOMED IMAGING AS (NO) 2001-10-30 US disclosed