Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596191 | 0.94 | ALDH1A1 (0.49) | ALDH1A1HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7601057 | 0.93 | ALDH1A1 (0.48) | ALDH1A1DRD2HTR1AHTR7 | |
| SCHEMBL7594407 | 0.91 | ALDH1A1 (0.45) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7602690 | 0.89 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7630436 | 0.87 | ALDH1A1 (0.42) | ALDH1A1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6771866 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL7599828 | 0.86 | ALDH1A1 (0.41) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7599330 | 0.85 | FPR3 (0.41) | ALDH1A1DRD3HPGDSMN1; SMN2 | |
| SCHEMBL7603379 | 0.84 | HTR1A (0.52) | ALDH1A1HTR2AHTR2CDRD2HTR1A | |
| SCHEMBL7608410 | 0.82 | PKM (0.42) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |