Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30179515 | 0.86 | CES2 (0.56) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL11169142 | 0.86 | CES2 (0.56) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL31514652 | 0.83 | GPR35 (0.62) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL45190 | 0.82 | ALDH1A1 (0.62) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL14114749 | 0.81 | SMN1; SMN2 (0.61) | ALDH1A1HPGDMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL130412 | 0.80 | DTYMK (0.64) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL2243892 | 0.79 | GPR35 (0.56) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL13010942 | 0.79 | GPR35 (0.56) | GPR35ALDH1A1TP53HPGDTSHR | |
| Lithium Ion SCHEMBL29084333 | 0.79 | GPR35 (0.56) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL29204387 | 0.79 | ALDH1A1 (0.51) | GPR35ALDH1A1TP53MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441189-B1 | WHICH REDUCES RACEMIZATION; (4R)-4-(HYDROXYMETHYL)-1,3-OXAZOLIDIN-2-ONE BY REDUCTION AND BASIFICATION OF THE CORRESPONDING 4-PROTECTED CARBOXY ESTER | ABBOTT LABORATORIES | 2002-08-27 | — | — | US | disclosed |
| US-20020052511-A1 | Process for the preparation of matrix metalloproteinase inhibitors | BAILEY ANNE E (US) | 2002-05-02 | — | — | US | disclosed |
| US-20020019539-A1 | Process for the preparation of matrix metalloproteinase inhibitors | ABBOTT LABORATORIES | 2002-02-14 | — | — | US | disclosed |
| WO-2001074792-A2 | PROCESS FOR THE PREPARATION OF MATRIX METALLOPROTEINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-11 | — | — | WO | disclosed |
| CN-1157286-A | N,N-dimethyl-1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxamide | SANKYO CO (JP) | 1997-08-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052511-A1 | Process for the preparation of matrix metalloproteinase inhibitors | MMP9, TIMP3, MMP2 | GPR35 4879/4885ALDH1A1 1359/4885TP53 3456/4885 |
| US-20020019539-A1 | Process for the preparation of matrix metalloproteinase inhibitors | MMP9, TIMP3, MMP2 | GPR35 4879/4885ALDH1A1 1359/4885TP53 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.