Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775597 | 0.96 | TSHR (0.50) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| Lithium Ion SCHEMBL30776952 | 0.96 | TSHR (0.50) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL31441111 | 0.96 | TSHR (0.50) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| Acrylamide SCHEMBL812219 | 0.90 | TSHR (0.44) | TSHRTGM2ALDH1A1 | |
| SCHEMBL162366 | 0.81 | TSHR (0.54) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| Potassium Ion SCHEMBL3657892 | 0.81 | TSHR (0.54) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1775598 | 0.79 | TSHR (0.52) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| Ammonia Solution, Strong SCHEMBL7618985 | 0.79 | TSHR (0.52) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| Lithium SCHEMBL38660899 | 0.79 | TSHR (0.52) | TSHRTGM2CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL27967446 | 0.79 | TSHR (0.52) | TSHRTGM2CYP2C19ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440856-B1 | GOOD FOR CHEMICAL MECHANICAL POLISHING ABRASIVE PARTICLES SUCH AS SILICA AND ALUMINA; POLYMER OR COPOLYMER HAVING AT LEAST ONE GROUP SELECTED FROM THE GROUP CONSISTING OF SULFONIC ACID AND CARBOXYLIC ACID | JSR CORPORATION (JP) | 2002-08-27 | — | — | US | disclosed |