Propylene Oxide

Propylene Oxide

SCHEMBL7628565

CC1CO1.Nc1ccccc1N

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.53
ALOX15 P16050 2/20 0.53
CASP1 P29466 1/20 0.53
CASP7 P55210 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
GAA P10253 3/20 0.41
USP2 O75604 2/20 0.41
TDP1 Q9NUW8 2/20 0.40
ALDH1A1 P00352 4/20 0.39
L3MBTL1 Q9Y468 3/20 0.39
TSHR P16473 5/20 0.39
PIK3CA P42336 1/20 0.38
ADRA2B P18089 1/20 0.37
PTGS1 P23219 1/20 0.37
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Questiomycin B SCHEMBL27861973 0.83 ALOX15 (0.60) CYP3A4ALOX15CASP1CASP7SMN1; SMN2
Aniline SCHEMBL9226304 0.82 TSHR (0.55) CYP3A4MEN1KMT2ATDP1ALDH1A1
Propylene Oxide SCHEMBL7628559 0.78 MAPT (0.47) CYP3A4ALOX15CASP1SMN1; SMN2MEN1
Biphenyl SCHEMBL1950563 0.76 ALDH1A1 (0.50) SMN1; SMN2MEN1KMT2AALDH1A1TSHR
Anthracene SCHEMBL27883190 0.74 CYP2A6 (0.39) CYP3A4ALOX15CASP1CASP7TDP1
Catechol SCHEMBL8055246 0.74 ALDH1A1 (0.53) CYP3A4ALOX15SMN1; SMN2TDP1ALDH1A1
Chlorobenzene SCHEMBL29027164 0.74 TSHR (0.58) MEN1KMT2ATDP1ALDH1A1L3MBTL1
Toluene SCHEMBL27963582 0.74 ACHE (0.58) SMN1; SMN2MEN1KMT2ATDP1ALDH1A1
Propylene Oxide SCHEMBL7623275 0.73 PNMT (0.43) SMN1; SMN2ALDH1A1L3MBTL1TSHRKDM4E
Ethane SCHEMBL21408556 0.73 CYP3A4 (0.83) CYP3A4ALOX15CASP1CASP7SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0724908-B1 Process for hydrogenating an aromatic ring containing compound using a ruthenium Raney catalyst SHOWA DENKO KK (JP) 2002-04-24 EP disclosed
US-6245920-B1 REACTING A 5-MEMBERED CYCLIC CARBOXYLIC ANHYDRIDE WITH HYDROGEN IN THE PRESENCE OF NOBLE METAL RANEY CATALYST TO REDUCE A CARBONYLOXY GROUP OF THE COMPOUND INTO A METHYLENEOXY GROUP TO CREATE A 5-MEMBERED LACTONE RING SHOWA DENKO K.K. (JP) 2001-06-12 US disclosed
US-6215030-B1 CATALYTIC REDUCTION OF ACIDS, ESTERS AND ANHYDRIDES TO ALCOHOLS SHOWA DENKO K.K. (JP) 2001-04-10 US disclosed
US-6018048-A PREPARING COMPOUNDS WITH HYDROGENATED RING STRUCTURE BY REACTING AN AROMATIC RING-CONTAINING COMPOUND WITH HYDROGEN IN THE PRESENCE OF A RANEY CATALYST COMPRISING AT LEAST 50% WEIGHT OF RUTHENIUM; MILDER TEMPERATURE, PRESSURE CONDITIONS SHOWA DENKO K.K. (JP) 2000-01-25 US disclosed
EP-0934920-A2 Preparation of hydrogenated compounds using noble metal Raney catalysts SHOWA DENKO KABUSHIKI KAISHA (JP) 1999-08-11 EP disclosed
EP-0724908-A1 Noble metal raney catalysts and preparation of hydrogenated compounds using such catalysts SHOWA DENKO KABUSHIKI KAISHA (JP) 1996-08-07 EP disclosed