Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 9/20 | 0.41 |
| ▸ | DRD4 | P21917 | 9/20 | 0.41 |
| ▸ | DRD3 | P35462 | 9/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458648 | 0.95 | ITGB3 (0.40) | LMNACA2ITGB3ITGA2BDRD2 | |
| SCHEMBL9151283 | 0.84 | HTR1A (0.45) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL8804880 | 0.84 | HTR1A (0.45) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL8805795 | 0.81 | ITGB3 (0.51) | LMNACA2ITGB3ITGA2BHTR6 | |
| SCHEMBL9127805 | 0.81 | ITGB3 (0.51) | LMNACA2ITGB3ITGA2BHTR6 | |
| SCHEMBL7636277 | 0.81 | ITGB3 (0.48) | LMNACA2ITGB3ITGA2BDRD2 | |
| SCHEMBL7631192 | 0.81 | CA2 (0.57) | LMNACA2DRD2DRD4DRD3 | |
| SCHEMBL7634476 | 0.80 | DRD2 (0.39) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL8317334 | 0.80 | ITGB3 (0.51) | LMNACA2ITGB3ITGA2BDRD2 | |
| SCHEMBL7628633 | 0.77 | MAOA (0.41) | LMNAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888327-B1 | BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | MENARINI LAB (ES) | 2002-06-12 | — | — | EP | disclosed |
| US-5990142-A | ANTIINFLAMMATORY AGENTS AND ANTIALLERGENS HAVING GOOD ORAL ADSORPTION AND BIOAVAILABILITY; CARDIOTONIC AND ANTIISCHEMIC AGENTS | LABORATORIOS MENARINI S.A. (ES) | 1999-11-23 | — | — | US | disclosed |