Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7640202 | 0.86 | CHRNB2 (0.32) | CHRNB2CHRNA4ACHENOS3NOS1 | |
| Hydrochloric Acid SCHEMBL338766 | 0.79 | CYP11B1 (0.33) | HTR2C | |
| Hydrochloric Acid SCHEMBL649477 | 0.79 | CYP11B1 (0.33) | HTR2C | |
| Hydrochloric Acid SCHEMBL10711045 | 0.79 | CYP11B1 (0.33) | HTR2C | |
| Hydrochloric Acid SCHEMBL1030910 | 0.75 | CYP1A2 (0.37) | — | |
| Fluoride Ion SCHEMBL1130323 | 0.75 | HTR2C (0.31) | HTR2C | |
| Hydrochloric Acid SCHEMBL5351284 | 0.72 | CYP19A1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL5515666 | 0.72 | CYP19A1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL6433415 | 0.72 | DRD2 (0.32) | — | |
| Hydrochloric Acid SCHEMBL28994366 | 0.71 | ACHE (0.32) | CHRNB2CHRNA4HTR2CACHESLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143911-A | Catalyst useful for the polymerization of olefins | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 2000-11-07 | — | — | US | claimed |
| US-5561093-A | Catalyst useful for the polymerization of olefins | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-10-01 | — | — | US | claimed |
| EP-0529908-B2 | Catalyst useful for the polymerization of olefin | MITSUBISHI CHEM CORP (JP) | 2002-11-06 | — | — | EP | disclosed |
| EP-0748822-B1 | Catalyst component useful for the polymerization of olefins | MITSUBISHI CHEM CORP (JP) | 2001-11-07 | — | — | EP | disclosed |
| US-6143911-A | Catalyst useful for the polymerization of olefins | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0529908-B1 | Catalyst useful for the polymerization of olefin | MITSUBISHI CHEM CORP (JP) | 1997-05-14 | — | — | EP | disclosed |
| EP-0748822-A2 | Catalyst component useful for the polymerization of olefins | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5561093-A | Catalyst useful for the polymerization of olefins | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-10-01 | — | — | US | disclosed |
| EP-0529908-A1 | Catalyst useful for the polymerization of olefin | MITSUBISHI CHEMICAL CORPORATION (JP) | 1993-03-03 | — | — | EP | disclosed |