Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7640005 | 0.78 | PPARG (0.41) | PPARGTBXA2RHSD11B1ALDH1A1LMNA | |
| SCHEMBL5048109 | 0.69 | TAS2R14 (0.69) | TAS2R14PTGESALOX5ALDH1A1LMNA | |
| SCHEMBL7639994 | 0.68 | PPARG (0.39) | PPARGTBXA2RALDH1A1MAPT | |
| SCHEMBL6059002 | 0.67 | ALDH1A1 (0.60) | TAS2R14PTGESALOX5ALDH1A1LMNA | |
| SCHEMBL6059008 | 0.67 | MMP2 (0.33) | PPARGTBXA2RTAS2R14PTGESALOX5 | |
| SCHEMBL5043193 | 0.65 | TAS2R14 (0.56) | TAS2R14PTGESALOX5MEN1KMT2A | |
| SCHEMBL5043627 | 0.65 | TAS2R14 (0.53) | TAS2R14MEN1KMT2A | |
| SCHEMBL5133321 | 0.65 | FABP4 (0.49) | TAS2R14ALDH1A1LMNAMEN1HTT | |
| SCHEMBL7640003 | 0.65 | TAS2R14 (0.43) | TAS2R14HSD11B1MEN1HTTKMT2A | |
| SCHEMBL5046836 | 0.63 | TAS2R14 (0.53) | TAS2R14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |