Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | FABP2 | P12104 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195441 | 0.87 | MEN1 (0.36) | PTGS1KMT2AMEN1AKR1C3AKR1C2 | |
| SCHEMBL9195448 | 0.87 | SMN1; SMN2 (0.36) | PTGS1KMT2AMEN1AKR1C3AKR1C2 | |
| SCHEMBL9705872 | 0.77 | FFAR1 (0.47) | PTGS1KMT2AMEN1AKR1C3AKR1C2 | |
| SCHEMBL9617615 | 0.76 | PTGES (0.39) | PTGS1KMT2AMEN1AKR1C3AKR1C2 | |
| SCHEMBL20773094 | 0.75 | CDK1 (0.44) | PTGS1KMT2AMEN1AKR1C3AKR1C2 | |
| SCHEMBL10790397 | 0.75 | STING1 (0.39) | PTGS1KMT2AMEN1AKR1C3AKR1C2 | |
| SCHEMBL7505997 | 0.74 | HDAC3 (0.46) | LMNAMAPTCYP1A2HPGDHIF1A | |
| SCHEMBL7503214 | 0.74 | HDAC3 (0.42) | LMNACYP1A2HIF1AFFAR1SMN1; SMN2 | |
| SCHEMBL10871117 | 0.73 | KMT2A (0.49) | KMT2AMEN1LMNAMAPTTSHR | |
| SCHEMBL28329663 | 0.72 | BCAT2 (0.47) | PTGS1KMT2AMEN1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0465879-B1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZK USTAV FARM BIOCHEM SP (CS) | 1995-11-29 | — | — | EP | claimed |
| US-5177204-A | Antiinflammatory agents | Vyzkumng, USTAV pro farmacii a biochemii, Statni podnik (CS) | 1993-01-05 | — | — | US | claimed |
| EP-0465879-A1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZKUMNY USTAV PRO FARMACII A BIOCHEMII STATNI PODNIK (CS) | 1992-01-15 | — | — | EP | claimed |
| EP-0180290-B1 | OMEGA-(2',4'-DIHALOBIPHENYLYL)OXO ALKANOIC ACIDS AND PROCESS FOR THEIR PREPARATION | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1987-10-28 | — | — | EP | claimed |
| EP-0180290-A1 | Omega-(2',4'-dihalobiphenylyl)oxo alkanoic acids and process for their preparation | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1986-05-07 | — | — | EP | claimed |
| EP-0790974-B1 | SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS | BAYER AG (US) | 2002-08-14 | — | — | EP | disclosed |
| EP-0465879-B1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZK USTAV FARM BIOCHEM SP (CS) | 1995-11-29 | — | — | EP | disclosed |
| EP-0465879-B1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZK USTAV FARM BIOCHEM SP (CS) | 1995-11-29 | — | — | EP | disclosed |
| US-5177204-A | Antiinflammatory agents | Vyzkumng, USTAV pro farmacii a biochemii, Statni podnik (CS) | 1993-01-05 | — | — | US | disclosed |
| US-5177204-A | Antiinflammatory agents | Vyzkumng, USTAV pro farmacii a biochemii, Statni podnik (CS) | 1993-01-05 | — | — | US | disclosed |
| US-5177204-A | Antiinflammatory agents | Vyzkumng, USTAV pro farmacii a biochemii, Statni podnik (CS) | 1993-01-05 | — | — | US | disclosed |
| EP-0465879-A1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZKUMNY USTAV PRO FARMACII A BIOCHEMII STATNI PODNIK (CS) | 1992-01-15 | — | — | EP | disclosed |
| EP-0465879-A1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZKUMNY USTAV PRO FARMACII A BIOCHEMII STATNI PODNIK (CS) | 1992-01-15 | — | — | EP | disclosed |
| EP-0465879-A1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZKUMNY USTAV PRO FARMACII A BIOCHEMII STATNI PODNIK (CS) | 1992-01-15 | — | — | EP | disclosed |