Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195441 | 0.88 | MEN1 (0.36) | SMN1; SMN2PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL7642234 | 0.87 | PTGS1 (0.46) | SMN1; SMN2PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL27566861 | 0.68 | NLRP3 (0.45) | SMN1; SMN2KMT2ATSHRMAPTLMNA | |
| SCHEMBL30541236 | 0.67 | PTPN1 (0.43) | SMN1; SMN2TSHRMAPTLMNAHPGD | |
| SCHEMBL28373905 | 0.67 | PTPN1 (0.43) | SMN1; SMN2TSHRMAPTLMNAHPGD | |
| SCHEMBL9705872 | 0.66 | FFAR1 (0.47) | SMN1; SMN2PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL9617615 | 0.66 | PTGES (0.39) | PTGS1PTGS2MEN1KMT2ATSHR | |
| SCHEMBL28329663 | 0.66 | BCAT2 (0.47) | PTGS1PTGS2MEN1KMT2ATSHR | |
| SCHEMBL3867424 | 0.65 | AKR1C3 (0.53) | SMN1; SMN2PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL28372933 | 0.65 | PTGS1 (0.41) | SMN1; SMN2PTGS1PTGS2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0465879-B1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZK USTAV FARM BIOCHEM SP (CS) | 1995-11-29 | — | — | EP | disclosed |
| EP-0465879-A1 | Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid | VYZKUMNY USTAV PRO FARMACII A BIOCHEMII STATNI PODNIK (CS) | 1992-01-15 | — | — | EP | disclosed |