Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.54 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536918 | 0.83 | SNCA (0.54) | SNCAMAPTAPPACHEMEN1 | |
| Iodide SCHEMBL17870555 | 0.83 | SNCA (0.53) | RAB9ASNCAMAPTAPPACHE | |
| Iodide SCHEMBL17870554 | 0.83 | SNCA (0.53) | RAB9ASNCAMAPTAPPACHE | |
| Hydrochloric Acid SCHEMBL712985 | 0.82 | SNCA (0.53) | SNCAMAPTAPPACHEMEN1 | |
| Hydrochloric Acid SCHEMBL3451810 | 0.82 | SNCA (0.53) | SNCAMAPTAPPACHEMEN1 | |
| SCHEMBL16183105 | 0.81 | PTGS2 (0.53) | RAB9ASNCAMAPTAPPACHE | |
| SCHEMBL12601614 | 0.80 | RAB9A (0.44) | RAB9ASNCAPABPC1EIF4HMAPT | |
| SCHEMBL14393752 | 0.80 | ACHE (0.46) | RAB9ASNCAPABPC1EIF4HMAPT | |
| Iodide SCHEMBL8910694 | 0.79 | CHAT (0.64) | RAB9APABPC1EIF4HMAPTACHE | |
| Iodide SCHEMBL7644259 | 0.78 | CHAT (0.47) | RAB9ASNCAPABPC1EIF4HMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395556-B1 | DETECTING THE PRESENCE/CONCENTRATION OF AN ANALYTE; USING FLUORESCENT REFERENCE MOLECULES AND EXPOSE A SAMPLE TO THE REFERENCE MOLECULE; MEASURE INTENSITY CHANGES BY DETERMINING POLARIZATION AXES AFTER EXPOSURE TO A RADIATION SOURCE | LAKOWICZ JOSEPH R (US) | 2002-05-28 | — | — | US | disclosed |
| WO-2000028307-A1 | POLARIZATION BASED SENSING | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2000-05-18 | — | — | WO | disclosed |