Sugi Predict

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SCHEMBL76458

SCHEMBL76458

CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)C(=O)C1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 2/20 0.54
▸ MAPT P10636 3/20 0.48
▸ ALDH1A1 P00352 3/20 0.48
▸ LMNA P02545 1/20 0.48
▸ HRH3 Q9Y5N1 1/20 0.43
▸ ESR2 Q92731 1/20 0.43
▸ GPR119 Q8TDV5 4/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ ADORA1 P30542 1/20 0.43
▸ CASP6 P55212 1/20 0.42
▸ GFER P55789 1/20 0.42
▸ NAMPT P43490 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ ENPP2 Q13822 2/20 0.41
▸ LIPE Q05469 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1583382 0.89 ESR2 (0.52) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL12795832 0.89 GPR119 (0.54) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL1206883 0.88 ALDH1A1 (0.47) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL1583532 0.88 P2RX7 (0.51) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL14899254 0.88 MEN1 (0.54) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL3068738 0.88 GPR119 (0.53) NR1H2MAPTALDH1A1LMNAESR2
SCHEMBL1082128 0.87 ALDH1A1 (0.50) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL1665532 0.87 ALDH1A1 (0.53) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL21595254 0.86 GPR119 (0.48) NR1H2MAPTALDH1A1LMNAHRH3
SCHEMBL1583151 0.85 ROCK2 (0.47) NR1H2MAPTALDH1A1LMNAHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040087582-A1 Phenyl derivatives MERCK PATENT GESELLSCHAFT (DE) 2004-05-06 — — US claimed
US-11939314-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2024-03-26 — — US disclosed
US-20230028687-A1 QUINOLIN-2-ONE DERIVATIVES MERCK PATENT GMBH (DE) 2023-01-26 — — US disclosed
US-20220273659-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS NUVATION BIO OPERATING COMPANY LLC 2022-09-01 — — US disclosed
EP-3993802-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS Nuvation Bio Inc. (US) 2022-05-11 — — EP disclosed
CN-114340634-A Heterocyclic compounds as kinase inhibitors 诺维逊生物股份有限公司 2022-04-12 — — CN disclosed
US-11186562-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2021-11-30 — — US disclosed
US-11174241-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2021-11-16 — — US disclosed
US-11174241-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2021-11-16 — — US disclosed
CN-108473485-B Quinolin-2-one derivatives 默克专利股份公司 2021-11-02 — — CN disclosed
WO-2004087696-A1 PYRAZOLIDINE-1,2-DICARBOXYLDIPHENYLAMIDE DERIVATIVES AS COAGULATION FACTOR XA INHIBITORS FOR THE TREATMENT OF THROMBOSES MERCK PATENT GMBH (DE) 2004-10-14 — — WO disclosed
WO-2004046138-A1 CARBOXAMIDES MERCK PATENT GMBH (DE) 2004-06-03 — — WO disclosed
US-20040087582-A1 Phenyl derivatives MERCK PATENT GESELLSCHAFT (DE) 2004-05-06 — — US disclosed
WO-2004035039-A1 HETEROCYCLIC AMIDES AND THEIR USE IN TREATING THROMBOEMBOLIC DISEASES AND TUMORS MERCK PATENT GMBH (DE) 2004-04-29 — — WO disclosed
WO-2004035039-A1 HETEROCYCLIC AMIDES AND THEIR USE IN TREATING THROMBOEMBOLIC DISEASES AND TUMORS MERCK PATENT GMBH (DE) 2004-04-29 — — WO disclosed
US-20040082563-A1 Phenyl derivatives 3 MERCK PATENT GMBH (DE) 2004-04-29 — — US disclosed
EP-1368341-A1 PHENYL DERIVATIVES 3 MERCK PATENT GmbH (DE) 2003-12-10 — — EP disclosed
EP-1351938-A1 PHENYL DERIVATIVES MERCK PATENT GmbH (DE) 2003-10-15 — — EP disclosed
WO-2002074765-A1 PHENYL DERIVATIVES 3 MERCK PATENT GMBH (DE) 2002-09-26 — — WO disclosed
WO-2002057236-A1 PHENYL DERIVATIVES MERCK PATENT GMBH (DE) 2002-07-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11174241-B2 Quinolin-2-one derivatives KIT, CDK2, CDK1 NR1H2 2169/4885MAPT 4646/4885ALDH1A1 2614/4885
US-11939314-B2 Quinolin-2-one derivatives KIT, CDK2, CDK1 NR1H2 2169/4885MAPT 4646/4885ALDH1A1 2614/4885
US-20230028687-A1 QUINOLIN-2-ONE DERIVATIVES KIT, CDK2, CDK1 NR1H2 2169/4885MAPT 4646/4885ALDH1A1 2614/4885
US-20040082563-A1 Phenyl derivatives 3 F2, F11, F12 NR1H2 917/4885MAPT 4547/4885ALDH1A1 739/4885
US-20220273659-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS CDK4, CDK6, CDK8 NR1H2 4055/4885MAPT 3156/4885ALDH1A1 2992/4885
US-11186562-B2 Quinolin-2-one derivatives KIT, CDK2, CDK1 NR1H2 2169/4885MAPT 4646/4885ALDH1A1 2614/4885
US-20040087582-A1 Phenyl derivatives F2, F11, SERPINC1 NR1H2 423/4885MAPT 4360/4885ALDH1A1 489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.