Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646145 | 0.94 | MMP8 (0.46) | GRIN1GRIN2BMMP8MMP14CA14 | |
| SCHEMBL7646266 | 0.92 | S1PR1 (0.37) | GRIN1GRIN2BMMP8MMP14CA14 | |
| SCHEMBL7645204 | 0.78 | RHOC (0.45) | MMP8MMP14CA14MEN1MAPT | |
| SCHEMBL7648081 | 0.76 | EPHX1 (0.44) | ALOX15EPHX1EPHX2MEN1MAPT | |
| SCHEMBL7650077 | 0.76 | ALDH1A1 (0.59) | CYP3A4MAPTKMT2AKDM4ENPC1 | |
| SCHEMBL7646938 | 0.75 | RHOC (0.41) | CYP3A4ALOX15EPHX1MEN1MAPT | |
| SCHEMBL7648476 | 0.73 | MAPT (0.53) | MMP8ALOX15MEN1MAPTKMT2A | |
| SCHEMBL7650967 | 0.73 | THRB (0.43) | CYP3A4ALOX15MAPTL3MBTL1 | |
| SCHEMBL7651039 | 0.73 | ALDH1A1 (0.52) | CYP3A4MAPTKMT2AKDM4ENPC1 | |
| SCHEMBL7649208 | 0.72 | MMP2 (0.42) | MMP8MMP14CA14CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002100871-A1 | NEW COMPOUNDS USEFUL IN REFLUX DISEASE | ASTRAZENECA AB (SE) | 2002-12-19 | — | — | WO | claimed |
| WO-2002100871-A1 | NEW COMPOUNDS USEFUL IN REFLUX DISEASE | ASTRAZENECA AB (SE) | 2002-12-19 | — | — | WO | disclosed |