Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | PNP | P00491 | 2/20 | 0.38 |
| ▸ | IDH2 | P48735 | 3/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650049 | 0.84 | TRPV3 (0.43) | TRPV3NPSR1KDM4EDNM1CXCR4 | |
| SCHEMBL7663595 | 0.83 | TRPV3 (0.44) | TRPV3NPSR1KDM4EDNM1CXCR4 | |
| SCHEMBL7108772 | 0.81 | PNP (0.38) | KDM4EDNM1PNPTYMPPDCD1 | |
| SCHEMBL7103571 | 0.77 | PNP (0.42) | KDM4EDNM1PNPTYMPPDCD1 | |
| SCHEMBL27777044 | 0.74 | TYMP (0.40) | TRPV3KDM4EDNM1PNPTYMP | |
| SCHEMBL27756229 | 0.74 | TYMP (0.40) | TRPV3KDM4EDNM1PNPTYMP | |
| SCHEMBL27756230 | 0.74 | TYMP (0.40) | TRPV3KDM4EDNM1PNPTYMP | |
| SCHEMBL10533348 | 0.73 | DNM1 (0.57) | KDM4EDNM1 | |
| SCHEMBL3079282 | 0.73 | DNM1 (0.57) | KDM4EDNM1 | |
| SCHEMBL7657692 | 0.73 | CD274 (0.46) | KDM4EDNM1CXCR4PNPPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |