Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPOR | P19235 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DDO | Q99489 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380603 | 0.76 | CPA3 (0.41) | KDM4EHPGDHSD17B10EPORTSHR | |
| SCHEMBL7653284 | 0.75 | ADAM17 (0.45) | KDM4EMAPTHPGDTSHRMEN1 | |
| SCHEMBL7653130 | 0.71 | PARP1 (0.34) | EPORMEN1KMT2AALDH1A1 | |
| SCHEMBL7644687 | 0.70 | HDAC1 (0.38) | KDM4EHPGDHSD17B10EPORTSHR | |
| SCHEMBL7647686 | 0.70 | CCKBR (0.39) | CCKBRKDM4EDAOMAPTHPGD | |
| SCHEMBL3103110 | 0.69 | KDM4E (0.43) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL5851328 | 0.69 | ALOX5 (0.51) | CCKBRKDM4EDAOMAPTHPGD | |
| SCHEMBL7648560 | 0.69 | POLB (0.38) | KDM4EMAPTHPGDHSD17B10EPOR | |
| SCHEMBL7645872 | 0.68 | BCHE (0.36) | KDM4EHPGDHSD17B10EPORTSHR | |
| SCHEMBL8661426 | 0.67 | KDM4E (0.46) | CCKBRKDM4EDAOMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |