Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651882 | 0.82 | ADORA3 (0.54) | FEN1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7653151 | 0.82 | KDM4E (0.44) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7648323 | 0.80 | SMN1; SMN2 (0.41) | LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL7653637 | 0.80 | MPO (0.43) | FEN1KDM4EALDH1A1HSD17B10CA12 | |
| SCHEMBL8133826 | 0.79 | KDM4E (0.45) | LMNAFEN1KDM4EALDH1A1HPGD | |
| SCHEMBL7650104 | 0.78 | FEN1 (0.58) | FEN1 | |
| SCHEMBL16265009 | 0.78 | RXFP1 (0.45) | LMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL7652823 | 0.78 | CA9 (0.58) | LMNAKDM4EHPGDGRIN2DGRIN3B | |
| SCHEMBL7655193 | 0.78 | CA12 (0.58) | LMNAALDH1A1HPGDCA12CA9 | |
| SCHEMBL7650006 | 0.69 | FEN1 (0.58) | FEN1ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |