Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 2/20 | 0.58 |
| ▸ | MPO | P05164 | 10/20 | 0.51 |
| ▸ | XDH | P47989 | 4/20 | 0.51 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22745955 | 0.85 | FEN1 (0.60) | FEN1MPOXDHDAOKEAP1 | |
| SCHEMBL8133826 | 0.84 | KDM4E (0.45) | FEN1DAOMEN1KMT2AGABRA1 | |
| SCHEMBL7655193 | 0.83 | CA12 (0.58) | MPOXDHDAOMEN1KMT2A | |
| SCHEMBL16265009 | 0.83 | RXFP1 (0.45) | DDR1MEN1KMT2A | |
| SCHEMBL7653637 | 0.83 | MPO (0.43) | FEN1MPOXDHDAO | |
| SCHEMBL7651932 | 0.82 | FEN1 (0.51) | FEN1MPOXDHKEAP1NFE2L2 | |
| SCHEMBL7651882 | 0.80 | ADORA3 (0.54) | FEN1MPOKMT2A | |
| SCHEMBL7650012 | 0.79 | MPO (0.44) | FEN1MPOXDHKMT2A | |
| SCHEMBL7651163 | 0.78 | LMNA (0.44) | FEN1 | |
| SCHEMBL7652823 | 0.75 | CA9 (0.58) | MPOXDHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |