Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 4/20 | 0.43 |
| ▸ | XDH | P47989 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.33 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650104 | 0.83 | FEN1 (0.58) | MPOXDHDAOFEN1 | |
| SCHEMBL7651849 | 0.81 | MPO (0.38) | MPOXDHDAOPARGKDM4E | |
| SCHEMBL7651163 | 0.80 | LMNA (0.44) | FEN1CA12CA9KDM4EALDH1A1 | |
| SCHEMBL8133826 | 0.78 | KDM4E (0.45) | DAOFEN1KDM4EALDH1A1POLB | |
| SCHEMBL7652823 | 0.77 | CA9 (0.58) | MPOXDHCA12CA9KDM4E | |
| SCHEMBL7655193 | 0.77 | CA12 (0.58) | MPOXDHDAOCA12CA9 | |
| SCHEMBL16265009 | 0.77 | RXFP1 (0.45) | ALDH1A1POLBHSD17B10 | |
| SCHEMBL7650006 | 0.74 | FEN1 (0.58) | DAOFEN1 | |
| SCHEMBL17191921 | 0.69 | SRC (0.44) | FEN1CA12CA9KDM4EALDH1A1 | |
| SCHEMBL6668697 | 0.69 | CA9 (0.59) | MPOXDHDAOPARGFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |