Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648470 | 0.89 | C3AR1 (0.53) | C3AR1CASP3ALDH1A1POLBHPGD | |
| SCHEMBL7648460 | 0.89 | C3AR1 (0.53) | C3AR1CASP3ALDH1A1POLBHPGD | |
| SCHEMBL7649508 | 0.82 | KMT2A (0.54) | C3AR1CASP3POLBHPGDRECQL | |
| SCHEMBL7651910 | 0.82 | KMT2A (0.54) | C3AR1CASP3POLBHPGDRECQL | |
| SCHEMBL7649702 | 0.80 | POLB (0.52) | C3AR1ALDH1A1POLBHPGDMAPT | |
| SCHEMBL7860325 | 0.79 | C3AR1 (0.45) | C3AR1OGG1KMT2A | |
| SCHEMBL7652750 | 0.79 | MTNR1A (0.40) | ALDH1A1POLBHPGDCYP2D6MTNR1A | |
| SCHEMBL7653534 | 0.75 | GPR34 (0.57) | C3AR1MAPTMEN1KMT2A | |
| SCHEMBL7859236 | 0.74 | C3AR1 (0.49) | C3AR1ALDH1A1POLBTP53MEN1 | |
| SCHEMBL3256313 | 0.73 | MEN1 (0.57) | ALDH1A1HPGDCYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489339-B1 | C3A receptor ligands | SMITHKLINE BEECHAM CORPORATION | 2002-12-03 | — | — | US | claimed |
| EP-1119357-A1 | C3A RECEPTOR LIGANDS | SmithKline Beecham Corporation (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000009129-A1 | C3A RECEPTOR LIGANDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-24 | — | — | WO | claimed |
| US-6489339-B1 | C3A receptor ligands | SMITHKLINE BEECHAM CORPORATION | 2002-12-03 | — | — | US | disclosed |
| EP-1119357-A1 | C3A RECEPTOR LIGANDS | SmithKline Beecham Corporation (US) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000009129-A1 | C3A RECEPTOR LIGANDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-24 | — | — | WO | disclosed |