Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654685 | 0.92 | PSEN1 (0.42) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7651232 | 0.90 | RORA (0.41) | ALDH1A1L3MBTL1LMNAKDM4EHPGD | |
| SCHEMBL7654237 | 0.88 | PER2 (0.38) | ALDH1A1LMNAKDM4EHTTTNF | |
| SCHEMBL7650485 | 0.87 | HDAC1 (0.38) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7655134 | 0.85 | TNF (0.51) | ALDH1A1L3MBTL1LMNAKDM4EHPGD | |
| SCHEMBL7648481 | 0.85 | MAPT (0.46) | ALDH1A1LMNA | |
| SCHEMBL7649601 | 0.85 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1LMNAKDM4ETSHR | |
| SCHEMBL7651184 | 0.85 | ALDH1A1 (0.50) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7654850 | 0.85 | ALDH1A1 (0.50) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7653084 | 0.82 | TNF (0.52) | ALDH1A1L3MBTL1LMNAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |