Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CNR2 | P34972 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655134 | 0.97 | TNF (0.51) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7651184 | 0.96 | ALDH1A1 (0.50) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7654850 | 0.96 | ALDH1A1 (0.50) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7652234 | 0.85 | CNR2 (0.49) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7651131 | 0.84 | CNR2 (0.42) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7651232 | 0.84 | RORA (0.41) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7653483 | 0.82 | ALDH1A1 (0.44) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7654237 | 0.82 | PER2 (0.38) | TNFKDM4ELMNAALDH1A1CNR2 | |
| SCHEMBL7654685 | 0.82 | PSEN1 (0.42) | TNFKDM4ELMNAALDH1A1HTT | |
| SCHEMBL7649601 | 0.81 | ALDH1A1 (0.37) | TNFKDM4ELMNAALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |