Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652545 | 0.83 | ADORA3 (0.49) | HIF1AADORA3ALDH1A1MAPTADORA2A | |
| SCHEMBL7654505 | 0.81 | HIF1A (0.48) | HIF1AADORA3ALDH1A1MAPTPKM | |
| Dimethylamine SCHEMBL7655912 | 0.79 | HIF1A (0.43) | HIF1AADORA3ALDH1A1MAPTADORA2A | |
| SCHEMBL7658153 | 0.79 | ADORA3 (0.51) | HIF1AADORA3ALDH1A1MAPTADORA2A | |
| SCHEMBL7658278 | 0.79 | MAPT (0.52) | ADORA3ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL7655906 | 0.76 | POLB (0.41) | HIF1AADORA3MAPTADORA2AADORA1 | |
| SCHEMBL15871239 | 0.76 | ADORA3 (0.53) | HIF1AADORA3ALDH1A1MAPTKDM4E | |
| SCHEMBL7657325 | 0.75 | ADORA3 (0.54) | HIF1AADORA3ALDH1A1MAPTADORA2A | |
| SCHEMBL7682175 | 0.74 | ALDH1A1 (0.55) | ADORA3ALDH1A1MAPTKDM4E | |
| SCHEMBL7649140 | 0.74 | TP53 (0.58) | ADORA3ALDH1A1MAPTADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492407-B2 | NEUROPROTECTIVE ACTIVITY | BOEHRINGER IMGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |