Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.49 |
| ▸ | NOS1 | P29475 | 5/20 | 0.46 |
| ▸ | NOS2 | P35228 | 5/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | F11 | P03951 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9677464 | 0.92 | LMNA (0.48) | ALDH1A1LMNA | |
| Benzyl Carbamate SCHEMBL9998168 | 0.87 | ALDH1A1 (0.55) | LOXL2ALDH1A1LMNA | |
| SCHEMBL28330985 | 0.85 | PRKCA (0.47) | ENPP2NOS1NOS2NOS3ALDH1A1 | |
| SCHEMBL5709288 | 0.84 | TPSAB1 (0.51) | LOXL2ALDH1A1PLG | |
| SCHEMBL6648255 | 0.84 | ALDH1A1 (0.43) | LOXL2ALDH1A1SMN1; SMN2LMNA | |
| Urethane SCHEMBL28735644 | 0.84 | ALOX15 (0.54) | ENPP2LOXL2NOS1NOS2NOS3 | |
| SCHEMBL27795850 | 0.84 | LMNA (0.42) | ALDH1A1LMNA | |
| SCHEMBL29011017 | 0.84 | ENPP2 (0.50) | ENPP2LOXL2NOS1NOS2NOS3 | |
| SCHEMBL31139242 | 0.84 | ALDH1A1 (0.43) | ALDH1A1LMNA | |
| SCHEMBL27664520 | 0.84 | ALDH1A1 (0.61) | ENPP2LOXL2NOS1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534152-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-02 | — | — | EP | disclosed |