Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655220 | 0.91 | HRH3 (0.39) | MCHR1HRH3OPRD1OPRM1 | |
| SCHEMBL7653613 | 0.86 | HSD11B1 (0.35) | RAPGEF3HRH3OPRD1 | |
| SCHEMBL7660195 | 0.84 | HRH3 (0.47) | RAPGEF3HRH3 | |
| SCHEMBL7654067 | 0.83 | HRH3 (0.60) | HRH3OPRD1OPRM1 | |
| SCHEMBL7658683 | 0.80 | HRH3 (0.42) | MCHR1HRH3OPRD1OPRM1 | |
| SCHEMBL6733733 | 0.77 | RAPGEF3 (0.39) | RAPGEF3MCHR1HRH3 | |
| SCHEMBL6734631 | 0.77 | RAPGEF3 (0.38) | RAPGEF3MCHR1HRH3 | |
| SCHEMBL7665084 | 0.76 | HRH3 (0.34) | HRH3OPRD1OPRM1 | |
| SCHEMBL7656218 | 0.75 | HRH3 (0.47) | HRH3 | |
| SCHEMBL6736042 | 0.75 | RAPGEF3 (0.43) | RAPGEF3MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469002-B1 | COMPOUNDS WHICH MODULATE CHEMOKINE RECEPTOR ACTIVITY AND ARE USEFUL IN TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. | 2002-10-22 | — | — | US | disclosed |