Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | GUSB | P08236 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653825 | 0.94 | ATM (0.58) | ATMNPC1RAB9ATNKSGUSB | |
| SCHEMBL7656031 | 0.86 | L3MBTL1 (0.58) | ATMNPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL7650664 | 0.85 | ADORA3 (0.44) | NPC1RAB9ATNKSPARP1TNKS2 | |
| SCHEMBL7652506 | 0.84 | TNKS (0.50) | ATMNPC1RAB9ATNKSPARP1 | |
| SCHEMBL20078779 | 0.81 | TNKS (0.50) | ATMNPC1RAB9ATNKSPARP1 | |
| SCHEMBL7660378 | 0.81 | ALDH1A1 (0.53) | NPC1RAB9ATNKSGUSBTNKS2 | |
| SCHEMBL15137129 | 0.79 | L3MBTL1 (0.48) | ATMNPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL7656228 | 0.79 | ALDH1A1 (0.49) | L3MBTL1SMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL4549461 | 0.78 | ALDH1A1 (0.37) | ATMHPGDALDH1A1KDM4EADORA3 | |
| SCHEMBL7652937 | 0.78 | TNKS (0.47) | NPC1RAB9ATNKSPARP1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492407-B2 | NEUROPROTECTIVE ACTIVITY | BOEHRINGER IMGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |