Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 14/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664466 | 0.90 | FKBP1A (0.48) | PTGESPTGS2FKBP1ANPC1RAB9A | |
| SCHEMBL27559144 | 0.86 | ALDH1A1 (0.44) | PTGESPTGS2FKBP1ANPC1RAB9A | |
| SCHEMBL7826244 | 0.86 | FKBP1A (0.48) | FKBP1ANPC1RAB9A | |
| SCHEMBL6737810 | 0.83 | PTGES (0.56) | PTGESPTGS2HCRTR1HCRTR2 | |
| SCHEMBL8027454 | 0.80 | FKBP1A (0.45) | FKBP1ANPC1RAB9A | |
| SCHEMBL6740429 | 0.80 | PTGES (0.54) | PTGESPTGS2 | |
| SCHEMBL7655863 | 0.75 | GABRP (0.45) | NPC1RAB9AHCRTR1HCRTR2 | |
| SCHEMBL6739627 | 0.75 | LMNA (0.52) | FKBP1A | |
| SCHEMBL23018138 | 0.73 | XDH (0.58) | PTGESPTGS2 | |
| SCHEMBL27479845 | 0.73 | LMNA (0.51) | NPC1RAB9AHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495549-B1 | 1-HETEROARYL-PIPERIDINE DERIVATIVES; MODERATING NEURONAL DEGENERATION; PROMOTING NEURONAL REGENERATION AND OUTGROWTH; TREATOG NEUROLOGICAL DISORDERS ARISING FROM NEURODEGENERATIVE DISEASES OR OTHER DISORDERS INVOLVING NERVE DAMAGE | PFIZER INC | 2002-12-17 | — | — | US | disclosed |
| CN-1315951-A | FKBP inhibitors | PFIZER LTD (US) | 2001-10-03 | — | — | CN | disclosed |