Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470167 | 0.91 | ITGB3 (0.43) | CCR5SFRP1ITGB3ITGA2BITGAV | |
| SCHEMBL7655428 | 0.86 | HPGDS (0.44) | SFRP1HPGDSITGB3ITGA2BITGAV | |
| SCHEMBL383466 | 0.85 | CCR5 (0.46) | CCR5CKS1BSKP1SKP2HPGDS | |
| SCHEMBL382763 | 0.82 | ITGB3 (0.48) | SFRP1HPGDSITGB3ITGA2BITGAV | |
| SCHEMBL7664581 | 0.81 | ITGB3 (0.64) | ITGB3ITGA2BITGAV | |
| SCHEMBL383469 | 0.80 | CCR5 (0.42) | CCR5SFRP1CKS1BSKP1SKP2 | |
| SCHEMBL7662225 | 0.79 | ITGB3 (0.42) | SFRP1ITGB3ITGA2BITGAVALDH1A1 | |
| SCHEMBL382702 | 0.79 | ITGB3 (0.46) | HPGDSITGB3ITGA2BITGAVCASR | |
| SCHEMBL382545 | 0.79 | ITGB3 (0.46) | HPGDSITGB3ITGA2BITGAVCASR | |
| SCHEMBL7664593 | 0.78 | CCR5 (0.44) | CCR5SFRP1CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |