SCHEMBL76649

SCHEMBL76649

O=C(O)NCCCN1CCOCC1

nearest known ligand 0.68

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.68
LMNA P02545 2/20 0.66
KDM4E B2RXH2 2/20 0.66
HPGD P15428 1/20 0.66
DUSP3 P51452 1/20 0.66
ALDH1A1 P00352 4/20 0.62
MAPK1 P28482 1/20 0.62
HIF1A Q16665 1/20 0.62
RAB9A P51151 1/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
POLB P06746 1/20 0.58
EPHX1 P07099 1/20 0.57
TSHR P16473 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5658003 0.98 GAA (0.66) GAALMNAKDM4EHPGDDUSP3
SCHEMBL166433 0.89 TDP1 (0.58) GAALMNAHPGDALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL5657522 0.87 GLA (0.58) GAALMNAHPGDALDH1A1SMN1; SMN2
SCHEMBL2347336 0.87 GAA (0.70) GAALMNAKDM4EHPGDDUSP3
SCHEMBL13655375 0.87 LMNA (0.84) GAALMNAKDM4EHPGDDUSP3
SCHEMBL23699040 0.84 GAA (0.62) GAALMNAKDM4EHPGDDUSP3
SCHEMBL11742767 0.84 LMNA (0.69) GAALMNAKDM4EHPGDDUSP3
SCHEMBL8762651 0.84 GAA (0.66) GAALMNAKDM4EHPGDDUSP3
SCHEMBL2691461 0.84 GAA (0.66) GAALMNAKDM4EHPGDDUSP3
SCHEMBL3903156 0.84 GAA (0.76) GAALMNAKDM4EHPGDDUSP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4025574-B1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS INC (US) 2025-05-07 EP claimed
EP-4025574-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME Rigel Pharmaceuticals, Inc. (US) 2022-07-13 EP claimed
US-20210070743-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 US claimed
WO-2021046407-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 WO claimed
EP-0885239-B1 NOVEL STEROID CARBAMATES AS POTENTIATING AGENTS BATRA SATISH (SE) 2002-08-07 EP claimed
US-5480989-A Carbamates of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1996-01-02 US claimed
US-20230112865-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME MIDCAP FINANCIAL TRUST 2023-04-13 US disclosed
EP-4025574-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME Rigel Pharmaceuticals, Inc. (US) 2022-07-13 EP disclosed
EP-3950692-A1 NOVEL TRICYCLIC COMPOUNDS AbbVie Inc. (US) 2022-02-09 EP disclosed
CN-109053742-B Novel tricyclic compounds ABBVIE 公司 2021-06-15 CN disclosed
US-20210070743-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 US disclosed
WO-2021046407-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 WO disclosed
US-20210061813-A1 NOVEL TRICYCLIC COMPOUNDS ABBVIE INC. (US) 2021-03-04 US disclosed
EP-0885239-A1 NOVEL STEROID CARBAMATES AS POTENTIATING AGENTS Batra, Satish (SE) 1998-12-23 EP disclosed
WO-1997027211-A1 NOVEL STEROID CARBAMATES AS POTENTIATING AGENTS BATRA SATISH (SE) 1997-07-31 WO disclosed
US-5559120-A IMMUNOSUPPRESSANTS, ANTIINFLAMMATORY AGENTS, FUNGICIDES AND ANTITUMOR AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-09-24 US disclosed
US-5530121-A IMMUNOSUPPRESSANTS, ANTIINFLAMMATORY AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-06-25 US disclosed
US-5530007-A ANTITUMOR, ANTIINFLAMMATORY, ANTIFUNGAL, ANTIPROLIFERATIVE, IMMUNOSUPPRESSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-06-25 US disclosed
US-5508399-A USEFUL AS IMMUNOSUPPRESSANT, ANTIINFLAMMATORY, ANTIFUNGAL, ANTIPROLIFERATIVE AND ANTIUMOR AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-04-16 US disclosed
US-5480989-A Carbamates of rapamycin AMERICAN HOME PRODUCTS CORPORATION (US) 1996-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230112865-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 GAA 1692/4885LMNA 1539/4885KDM4E 3427/4885
US-20210061813-A1 NOVEL TRICYCLIC COMPOUNDS CYP11B2, CYP11B1, ABCB1 GAA 1449/4885LMNA 2521/4885KDM4E 4131/4885
US-20210070743-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 GAA 1692/4885LMNA 1539/4885KDM4E 3427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.