Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CPA3 | P15088 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674189 | 0.80 | CYP2D6 (0.54) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL2332638 | 0.79 | CYP2C19 (0.46) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL9035024 | 0.78 | GABBR2 (0.53) | CYP2C19CYP2D6CPA3MAPK1SRC | |
| SCHEMBL14360103 | 0.78 | GABBR2 (0.53) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL27720580 | 0.78 | GABBR2 (0.53) | CYP2C19CYP2D6CPA3MAPK1SRC | |
| SCHEMBL8107873 | 0.77 | RIPK1 (0.52) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL258372 | 0.77 | RIPK1 (0.52) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL14360050 | 0.77 | GABBR2 (0.52) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL991988 | 0.77 | RIPK1 (0.52) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL30937427 | 0.76 | CYP2D6 (0.46) | CYP2C19ALDH1A1CYP2D6CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355640-B1 | TREATMENT OF HYPERTENSION, UROGENITAL DISORDERS AND FORMED BY WITTIG REACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| CN-1046724-C | Pyrazolopyridine compounds, pharmaceutical compositions containing them, processes for their preparation and their use | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-24 | — | — | CN | disclosed |
| US-5773530-A | USEFUL AS PSYCHOSTIMULANTS, ANTIHYPERTENSIVE AGENTS AND REMEDIES FOR RENAL FAILURE, DIURETICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| CN-1139928-A | Novel compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-01-08 | — | — | CN | disclosed |
| EP-0737193-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018128-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-06 | — | — | WO | disclosed |