Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477740 | 0.69 | TDP1 (0.53) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL9922005 | 0.69 | LMNA (0.53) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL24701310 | 0.69 | LMNA (0.46) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL7879489 | 0.67 | TDP1 (0.44) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL14154413 | 0.66 | MAPK1 (0.37) | ALDH1A1NPC1MAPK1RAB9AMAPT | |
| SCHEMBL18869413 | 0.66 | MAPK1 (0.53) | LMNATDP1ALDH1A1MAPK1MAPT | |
| SCHEMBL7671126 | 0.66 | ALDH1A1 (0.49) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL11573009 | 0.66 | ALDH1A1 (0.59) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL14008970 | 0.65 | LMNA (0.49) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL4133572 | 0.65 | TGFBR1 (0.53) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |