Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664751 | 0.85 | HTR2A (0.40) | SLC6A4BCL2L2FEN1ALOX5APPOLB | |
| SCHEMBL7664372 | 0.85 | PLAU (0.41) | NPC1GAARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL7670839 | 0.85 | CYP11B1 (0.41) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL7672934 | 0.82 | TTR (0.34) | GAASLC6A4BCL2L2FYNFEN1 | |
| SCHEMBL7664066 | 0.76 | BCL2L2 (0.37) | SLC6A4BCL2L2FYNFEN1LTA4H | |
| SCHEMBL7666933 | 0.76 | CYP11B1 (0.42) | SMN1; SMN2BCL2L2FEN1LTA4HSREBF2 | |
| SCHEMBL7666947 | 0.74 | FEN1 (0.38) | BCL2L2FYNFEN1ALOX5APPOLB | |
| SCHEMBL7667019 | 0.70 | TRPA1 (0.41) | FEN1ALOX5APL3MBTL1SREBF2 | |
| SCHEMBL7664382 | 0.69 | SLC6A2 (0.43) | NPC1RAB9ASLC6A4L3MBTL1SREBF2 | |
| SCHEMBL7664578 | 0.68 | GRM5 (0.38) | SMN1; SMN2FEN1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |