Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | OXTR | P30559 | 2/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668578 | 0.80 | L3MBTL1 (0.36) | NPSR1CYP1A2CYP2C19CYP2D6CYP3A4 | |
| SCHEMBL7667019 | 0.78 | TRPA1 (0.41) | L3MBTL1SREBF2ALDH1A1HTT | |
| SCHEMBL7664382 | 0.77 | SLC6A2 (0.43) | NPSR1L3MBTL1SREBF2MAPTNPC1 | |
| SCHEMBL7666933 | 0.77 | CYP11B1 (0.42) | CYP1A2CYP2C19CYP2D6CYP3A4SREBF2 | |
| SCHEMBL7664578 | 0.76 | GRM5 (0.38) | MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7664066 | 0.72 | BCL2L2 (0.37) | NPSR1CYP2D6L3MBTL1SREBF2MAPT | |
| SCHEMBL7664751 | 0.72 | HTR2A (0.40) | L3MBTL1SLC6A4ALOX15 | |
| SCHEMBL7666947 | 0.71 | FEN1 (0.38) | MEN1KMT2ANPSR1L3MBTL1MAPT | |
| SCHEMBL10462079 | 0.70 | PDE5A (0.41) | SREBF2 | |
| SCHEMBL10462078 | 0.70 | PDE5A (0.41) | SREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |