SCHEMBL7667697

SCHEMBL7667697

C=Cc1ccc(-c2ccc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
KIF11 P52732 4/20 0.32
TSHR P16473 1/20 0.32
CYP1A2 P05177 1/20 0.31
HDAC2 Q92769 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21066247 0.94 ALDH1A1 (0.46) ALDH1A1TSHRCYP1A2
SCHEMBL8383958 0.92 ALDH1A1 (0.44) ALDH1A1TSHRCYP1A2
SCHEMBL476546 0.88 ALDH1A1 (0.48) ALDH1A1TSHRCYP1A2
SCHEMBL476554 0.80 ALDH1A1 (0.52) ALDH1A1TSHRCYP1A2
SCHEMBL16626146 0.80 ALDH1A1 (0.58) ALDH1A1CA1CA2TSHRCYP1A2
SCHEMBL21920722 0.78 KIF11 (0.54) ALDH1A1CA1CA2KIF11CYP1A2
SCHEMBL5513731 0.78 KIF11 (0.54) ALDH1A1CA1CA2KIF11CYP1A2
SCHEMBL673282 0.75 LMNA (0.43) CA1CA2
SCHEMBL1421311 0.75 KIF11 (0.56) ALDH1A1KIF11TSHRCYP1A2
SCHEMBL1005055 0.75 CYP1A2 (0.33) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6388146-B1 AROMATIC UNSATURATED NOMONER SHARP KABUSHIKI KAISHA (JP) 2002-05-14 US disclosed