Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664949 | 0.91 | PTGS2 (0.40) | PTGS2LMNACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7667718 | 0.83 | CYP19A1 (0.40) | PTGS2KDM4ETBXAS1AHRNPSR1 | |
| SCHEMBL7667706 | 0.83 | TBXAS1 (0.41) | PTGS2KDM4ETBXAS1AHRNPSR1 | |
| SCHEMBL7653717 | 0.81 | FNTA (0.51) | NPSR1 | |
| SCHEMBL7665403 | 0.76 | CYP19A1 (0.41) | PTGS2CYP19A1CYP11B1CYP11B2CYP51A1 | |
| SCHEMBL7653706 | 0.75 | PTGS2 (0.47) | PTGS2KDM4EAHRNPSR1CYP51A1 | |
| SCHEMBL7657859 | 0.74 | FNTA (0.51) | NPSR1 | |
| SCHEMBL7662187 | 0.73 | FNTA (0.52) | PTGS2CYP51A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7662191 | 0.72 | FNTA (0.38) | PTGS2LMNACYP51A1CYP3A4CYP2D6 | |
| SCHEMBL7664955 | 0.72 | CYP19A1 (0.45) | TBXAS1LMNACYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410539-B1 | ANTICARCINOGENIC AGENTS | ASTRAZENCA UK LIMITED (GB) | 2002-06-25 | — | — | US | disclosed |