Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5891827 | 0.86 | CYP19A1 (0.36) | KIF11MAOBCYP19A1 | |
| SCHEMBL8149150 | 0.83 | NR3C1 (0.35) | MAOBCYP19A1ALDH1A1HTTLMNA | |
| SCHEMBL7677950 | 0.80 | CYP11B1 (0.36) | — | |
| SCHEMBL8155413 | 0.79 | ALDH1A1 (0.36) | MAOBCYP19A1ALDH1A1 | |
| SCHEMBL8157364 | 0.79 | XDH (0.36) | CYP19A1ALDH1A1 | |
| SCHEMBL7664213 | 0.78 | KIF11 (0.36) | KIF11 | |
| SCHEMBL8109079 | 0.78 | AR (0.36) | SLC6A2SLC6A4HPGDS | |
| SCHEMBL8155536 | 0.78 | IMPDH2 (0.36) | MAOB | |
| SCHEMBL8150877 | 0.74 | CYP2D6 (0.35) | SLC6A2SLC6A4 | |
| SCHEMBL7663652 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407132-B1 | ANTIHISTAMINES, ANTIALLERGENS, ANTIASTHMATICS, ANTICONVULSANTS, AND ANTIDEPRESSANTS; SKIN RASH TREATMENT | JAMES BLACK FOUNDATION LIMITED (GB) | 2002-06-18 | — | — | US | disclosed |
| US-6093737-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-07-25 | — | — | US | disclosed |
| EP-1003374-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1003374-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998028980-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |