Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671417 | 0.87 | GAA (0.39) | ALDH1A1KDM4E | |
| SCHEMBL7672504 | 0.79 | NR1H2 (0.40) | PDE3BPDE3AMAPTADORA2AADORA1 | |
| SCHEMBL8867321 | 0.75 | THRB (0.37) | ALDH1A1NR1H2FEN1TOP2ATOP2B | |
| SCHEMBL11494803 | 0.69 | PDE3B (0.43) | PDE3BPDE3AADORA2AADORA1ALDH1A1 | |
| SCHEMBL7664619 | 0.69 | COMT (0.36) | MAPTADORA2AADORA1ALDH1A1KDM4E | |
| SCHEMBL27691202 | 0.68 | AKR1A1 (0.48) | MAPTALDH1A1ATMKDM4EHTR6 | |
| SCHEMBL7666716 | 0.68 | SMN1; SMN2 (0.39) | MAPTALDH1A1ATMKDM4E | |
| SCHEMBL7669227 | 0.68 | VKORC1 (0.38) | ALDH1A1KDM4EHPGDLMNASIRT2 | |
| SCHEMBL7668581 | 0.68 | GSK3B (0.37) | ALDH1A1 | |
| SCHEMBL12850750 | 0.63 | GPR84 (0.79) | ALDH1A1HTR6LMNAGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |