Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672764 | 0.86 | HTR2A (0.46) | HTR2ASLC6A4KCNH2CYP1A2CYP2C19 | |
| SCHEMBL7667163 | 0.84 | ALDH1A1 (0.47) | S1PR4LMNAKMT2AL3MBTL1MEN1 | |
| SCHEMBL7666787 | 0.83 | MAPT (0.43) | HTR2ASLC6A4KCNH2HTR2CHTR2B | |
| SCHEMBL7668891 | 0.80 | HTR2A (0.41) | HTR2ASLC6A4KCNH2CYP1A2CYP2C19 | |
| SCHEMBL7666802 | 0.80 | TRPA1 (0.44) | SLC6A4KCNH2S1PR4KMT2ATRPA1 | |
| SCHEMBL7659649 | 0.79 | ADORA1 (0.34) | HTR2ASLC6A4KCNH2S1PR4 | |
| SCHEMBL6293301 | 0.73 | HSPB1 (0.43) | HTR2ASLC6A4KCNH2LMNAL3MBTL1 | |
| SCHEMBL3949976 | 0.72 | TGFBR1 (0.41) | SCN9AS1PR4 | |
| SCHEMBL7671126 | 0.72 | ALDH1A1 (0.49) | LMNAHTT | |
| SCHEMBL22199135 | 0.71 | S1PR4 (0.51) | HTR2ASLC6A4KCNH2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |