Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.46 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669835 | 0.87 | RXFP1 (0.61) | HSD17B10MEN1KMT2ARXFP1MAPT | |
| SCHEMBL7669130 | 0.87 | SGMS2 (0.67) | SGMS2GAAHSD17B10MEN1KMT2A | |
| SCHEMBL7674189 | 0.85 | NPC1 (0.58) | MEN1KMT2ARXFP1MAPTALDH1A1 | |
| SCHEMBL7671600 | 0.83 | ALDH1A1 (0.51) | GAAHSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL7671694 | 0.82 | KMT2A (0.55) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7670478 | 0.82 | TP53 (0.56) | GAAHSD17B10KMT2AMAPTALDH1A1 | |
| SCHEMBL7665180 | 0.82 | KDM4E (0.56) | HSD17B10MEN1KMT2AMAPTLMNA | |
| SCHEMBL7582747 | 0.81 | LMNA (0.65) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5892649 | 0.81 | MMP2 (0.67) | — | |
| SCHEMBL7669734 | 0.80 | MEN1 (0.52) | GAAHSD17B10MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |