Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668944 | 0.94 | KCNH2 (0.32) | RIPK1KCNH2FPR1FPR2CHRNA7 | |
| SCHEMBL7672515 | 0.91 | ALDH1A1 (0.35) | RIPK1KCNH2FPR1FPR2PKM | |
| SCHEMBL7661805 | 0.88 | LTA4H (0.45) | RIPK1KCNH2MEN1KMT2A | |
| SCHEMBL7664817 | 0.85 | PKM (0.35) | RIPK1KCNH2FPR1FPR2CYP1A2 | |
| SCHEMBL7668727 | 0.84 | KCNA5 (0.39) | RIPK1FPR1FPR2CYP1A2CYP3A4 | |
| SCHEMBL7670903 | 0.84 | FPR1 (0.32) | RIPK1FPR1FPR2CHRNA7PLA2G7 | |
| SCHEMBL7668596 | 0.84 | RIPK1 (0.35) | RIPK1FPR1FPR2CHRNA7PLA2G7 | |
| SCHEMBL7669021 | 0.84 | KCNA5 (0.33) | RIPK1FPR1FPR2CHRNA7PLA2G7 | |
| SCHEMBL7674840 | 0.84 | KCNA5 (0.39) | RIPK1FPR1FPR2CYP1A2CYP3A4 | |
| SCHEMBL7668560 | 0.83 | PTK2 (0.33) | KCNH2FPR1FPR2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |