Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672764 | 0.82 | HTR2A (0.46) | HTR2ASLC6A4KCNH2S1PR4 | |
| SCHEMBL7667163 | 0.80 | ALDH1A1 (0.47) | S1PR4 | |
| SCHEMBL7666787 | 0.79 | MAPT (0.43) | HTR2ASLC6A4KCNH2S1PR4 | |
| SCHEMBL7667111 | 0.79 | HTR2A (0.43) | HTR2ASLC6A4KCNH2S1PR4 | |
| SCHEMBL7671126 | 0.69 | ALDH1A1 (0.49) | — | |
| SCHEMBL3949976 | 0.69 | TGFBR1 (0.41) | S1PR4 | |
| SCHEMBL22199135 | 0.68 | S1PR4 (0.51) | HTR2ASLC6A4KCNH2S1PR4 | |
| SCHEMBL6652862 | 0.68 | MAOA (0.52) | — | |
| SCHEMBL7226169 | 0.68 | ALDH1A1 (0.42) | ADORA1S1PR4 | |
| SCHEMBL7670809 | 0.67 | S1PR4 (0.40) | S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6333341-B1 | TUMOR NECROSIS FACTOR, ANTIINFLAMMATORY AGENTS AND ANALGESICS | AMGEN INC. | 2001-12-25 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |