Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP14 | P50281 | 2/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5892649 | 0.90 | MMP2 (0.67) | ADAMTS4MMP2MMP9MMP14ADAM17 | |
| SCHEMBL7671694 | 0.90 | KMT2A (0.55) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7663740 | 0.88 | ALDH1A1 (0.65) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL7582747 | 0.88 | LMNA (0.65) | SMN1; SMN2MMP2MMP9MEN1KMT2A | |
| SCHEMBL7676245 | 0.87 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ADAMTS4MMP2 | |
| SCHEMBL7666345 | 0.86 | LMNA (0.57) | SMN1; SMN2MMP1MEN1KMT2ALMNA | |
| SCHEMBL7580808 | 0.85 | HSD17B10 (0.61) | NPC1RAB9ASMN1; SMN2MMP2MMP9 | |
| SCHEMBL7675460 | 0.85 | SGMS2 (0.58) | MEN1KMT2ARXFP1LMNAALDH1A1 | |
| SCHEMBL7667880 | 0.85 | LMNA (0.54) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL7670801 | 0.83 | LMNA (0.52) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |